Protein List

Your search: Assay in [Hemolytic]

Found 60 entries.


ID Name Class Organism Assay Summary
1 kalata B1 Cyclotide Viola odorata
Oldenlandia affinis
Viola tricolor
Hybanthus enneaspermus
Viola baoshanensis
Viola yedoensis
Viola philippica
Viola sumatrana Miq		 Tricyclon A has minimal haemolytic activity [...]
Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
Cycloviolacin H4 has potent haemolytic activity compared to kalata B1 [...]
Both [P20D/V21K]kalata B1 and [W19K/P20N/V21K]kalata B1 exhibited no haemolytic activity. Kalata B1 exhibited mild haemolytic activity. [...]
Both kalata B1 oia and B1 nfk exhibited no haemolytic activity [...]
At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
7 tricyclon A Cyclotide Viola odorata
Viola tricolor
Viola arvensis		 Tricyclon A has minimal haemolytic activity [...]
8 circulin A Cyclotide Chassalia parvifolia
Chassalia chartacea		 Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
9 N-KB1-C Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
10 Ac-KB1-C Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
11 N-KB1-Am Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
12 Ac-KB1-Am Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
13 Ac-[desGly]-KB1-Am Cyclotide Synthetic Kalata B1 showed concentration dependent erythrocyte lysis. [...]
14 kalata b1-1 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
15 kalata b1-2 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
16 kalata b1-3 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
17 kalata b1-4 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
18 kalata b1-5 Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
19 kalata b1-6a Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
20 kalata b1-6b Cyclotide Synthetic Hemolytic activity for established for kalata B1 but not acyclic permutants [...]
21 cycloviolacin O2 Cyclotide Viola odorata
Hybanthus enneaspermus
Viola baoshanensis
Viola biflora
Viola philippica
Viola uliginosa
Viola arcuata
Viola austrosinensis
Viola anagae		 At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
22 des(24-28)kB1 Cyclotide Synthetic Resistance to enzymatic digest shown for kalata B1 and acyclic permutants. Reduced protein was susceptible. [...]
32 cyclopsychotride A Cyclotide Psychotria longipes Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
37 kalata S Cyclotide Viola odorata
Oldenlandia affinis
Viola tricolor
Viola arvensis
Viola baoshanensis
Viola yedoensis
Viola biflora
Viola philippica
Viola ignobilis
Viola uliginosa
Viola sumatrana Miq
Viola arcuata
Palicourea sessilis
Viola betonicifolia
Viola anagae		 Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
45 circulin B Cyclotide Chassalia parvifolia Hemolytic activity established for kalata B1, circulin A, circulin B and cyclopsychotride A [...]
52 cycloviolacin O4 Cyclotide Viola odorata
Viola tricolor
Viola baoshanensis
Pombalia calceolaria		 The toxicity of the cyclotides (anpy A, anpy B, cyO4, and cyO17) against human red blood cells. [...]
168 kalata B8 Cyclotide Oldenlandia affinis
Hybanthus enneaspermus		 Kalata B8 did not display haemolytic activity. [...]
169 cycloviolacin H4 Cyclotide Viola hederacea Cycloviolacin H4 has potent haemolytic activity compared to kalata B1 [...]
170 cycloviolacin O13 Cyclotide Viola odorata
Hybanthus enneaspermus
Viola baoshanensis
Viola uliginosa
Viola arcuata
Viola austrosinensis		 At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
172 violacin A Cyclotide Viola odorata
Psychotria leptothyrsa		 Violacin A showed markedly decreased hemolytic activity relative to the prototypic cyclotide kalata B1 [...]
174 cycloviolacin O14 Cyclotide Viola odorata At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
175 cycloviolacin O15 Cyclotide Viola odorata At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
177 cycloviolacin O17 Cyclotide Viola odorata The toxicity of the cyclotides (anpy A, anpy B, cyO4, and cyO17) against human red blood cells. [...]
184 cycloviolacin O24 Cyclotide Viola odorata At a concentration of 25 ºM, a more than 6-fold difference exists between the most hemolyticcyclotide, cycloviolacin O24 (~75% hemolysis), and the least hemolytic cyclotide cycloviolacin O14 (~11% hemolysis). The sensitivity of hemolytic activity to variations in the peptide sequence is evident when comparing cycloviolacin O2 and O13. Here, the only sequence deviation is a single residue substitution of a serine in loop 3 of O2 (HD50 ~36 ºM) to an alanine in the homologous position in O13 (HD50 ~11 ºM). The loss of this single hydroxy group changes the HD50 more than three-fold. [...]
234 [P20D,V21K]kalata B1 Cyclotide Synthetic Both [P20D/V21K]kalata B1 and [W19K/P20N/V21K]kalata B1 exhibited no haemolytic activity. Kalata B1 exhibited mild haemolytic activity. [...]
235 [W19K, P20N, V21K]kalata B1 Cyclotide Synthetic Both [P20D/V21K]kalata B1 and [W19K/P20N/V21K]kalata B1 exhibited no haemolytic activity. Kalata B1 exhibited mild haemolytic activity. [...]
240 kalata B1 oia Cyclotide Oldenlandia affinis Both kalata B1 oia and B1 nfk exhibited no haemolytic activity [...]
241 kalata B1 nfk Cyclotide Oldenlandia affinis Both kalata B1 oia and B1 nfk exhibited no haemolytic activity [...]
347 cycloviolacin Y1 Cyclotide Viola yedoensis Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
350 cycloviolacin Y4 Cyclotide Viola yedoensis Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
351 cycloviolacin Y5 Cyclotide Viola baoshanensis
Viola yedoensis		 Cycloviolacins Y4 and Y5 are the most hemolytic of the new cyclotides, both being more potent than the prototypic cyclotide kalata B1. By contrast, cycloviolacin Y1 is substantially less active than all of the other cyclotides tested. [...]
454 [G1A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
455 [L2A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
456 [P3A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
457 [V4A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
458 [G6A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
459 [E7A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
460 [T8A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
461 [V10A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
462 [G11A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
463 [G12A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
464 [T13A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
465 [N15A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
466 [T16A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
467 [P17A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
468 [G18A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
469 [T20A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
470 [S22A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
473 [V25A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
474 [T27A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
475 [R28A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
476 [N29A]kalata B1 Cyclotide Synthetic Substitution of certain residues of kalata B1 to alanine result in loss of hemolytic activity. Residues in loops 1 and 3 along with a few other isolated residues strongly affect activity. [...]
1961 anpy A Cyclotide Anchietea pyrifolia The toxicity of the cyclotides (anpy A, anpy B, cyO4, and cyO17) against human red blood cells. [...]
1962 anpy B Cyclotide Anchietea pyrifolia The toxicity of the cyclotides (anpy A, anpy B, cyO4, and cyO17) against human red blood cells. [...]
1963 anpy C Cyclotide Anchietea pyrifolia The toxicity of the cyclotides (anpy A, anpy B, cyO4, and cyO17) against human red blood cells. [...]