ID
Name
Class
Organism
Assay Summary
1325
HB9
Cyclotide
Hedyotis biflora
HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell
migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1324
HB8
Cyclotide
Hedyotis biflora
HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell
migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1323
HB7
Cyclotide
Hedyotis biflora
HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell
migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1322
HB6
Cyclotide
Hedyotis biflora
HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell
migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1321
HB5
Cyclotide
Hedyotis biflora
HB5-9 showed significant cytotoxicity on cancer cell lines BxPC3, Capan2, MOH1 and PANC1. HB7 inhibited the cell
migration and invasion of Capan2 cells and could significantly inhibit the tumour weight and size. [...]
1313
Parigidin-br3
Cyclotide
Palicourea rigida
Parigidin-br3 showed cytotoxic activity against MCF-7 (breast cancer) and CACO2 (colorectal adenocarcinoma) cells, with IC50 values of ∼2.5 μM and less than 10% hemolytic activity. [...]
1311
Rivi4
Cyclotide
Rinorea virgata
Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1310
Rivi3
Cyclotide
Rinorea virgata
Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1309
Rivi2
Cyclotide
Rinorea virgata
Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1308
Rivi1
Cyclotide
Rinorea virgata
Rivi1-4 showed cytotoxic activities against MDA-MB-231 (breast cancer), MM96L (melanoma), HT-29 (colon cancer), human umbilical vein endothelia cells (HUVECs) and HFF-1 (human foreskin fibroblast) cells. Rivil1 was the least toxic Rivi peptides, Rivi 2−4 had only slightly higher IC50 values than cycloviolacin O2 and showed minimal selectivity between the cell lines. Rivi1−3 did not show hemolytic activity. [...]
1220
DC3
Cyclotide
Hedyotis diffusa
DC1-3 demonstrated potent cytotoxicity in prostate cancer cells and DC3 had a lowest IC50 value. [...]
1218
DC2
Cyclotide
Hedyotis diffusa
DC1-3 demonstrated potent cytotoxicity in prostate cancer cells and DC3 had a lowest IC50 value. [...]
1217
DC1
Cyclotide
Hedyotis diffusa
DC1-3 demonstrated potent cytotoxicity in prostate cancer cells and DC3 had a lowest IC50 value. [...]
704
cyclolinopeptide B
Orbitide
Linum usitatissimum (flax)
cyclolinopeptide A and B exhibited apoptosis induction on SGC-7901 cells. [...]
703
cyclolinopeptide A
Orbitide
Linum usitatissimum (flax)
cyclolinopeptide A and B exhibited apoptosis induction on SGC-7901 cells. [...]
556
psyle E
Cyclotide
Psychotria leptothyrsa
Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...] Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...]
554
psyle C
Cyclotide
Psychotria leptothyrsa
Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...] Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...]
552
psyle A
Cyclotide
Psychotria leptothyrsa
Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...] Nonclonogenic fluorometric microculture cytotoxicity assay was performed on psyle A, C and E using U-937 GTB human lymphoma tumor cell line. [...]
359
vibi H
Cyclotide
Viola biflora Psychotria leptothyrsa
vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
358
vibi G
Cyclotide
Viola tricolor Viola biflora Psychotria leptothyrsa
vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
356
vibi E
Cyclotide
Viola biflora
vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
355
vibi D
Cyclotide
Viola biflora
vibi D, E, G and H were analysed using fluorometric microculture cytotoxicity assay using a lymphoma cell line. The IC50 values ranged between 0.96 and 5.0 uM for vibi E, G and H, and vibi D was not cytotoxic at 30 uM. [...]
239
([Lys(Ac)]2[Arg(CHD)])cyO2
Cyclotide
Synthetic
Glutamic acid mutant had reduced activity [...]
238
[Arg(CHD)]cyO2
Cyclotide
Synthetic
Glutamic acid mutant had reduced activity [...]
237
[Lys(Ac)]2cyO2
Cyclotide
Synthetic
Glutamic acid mutant had reduced activity [...]
236
[Glu(Me)]cyO2
Cyclotide
Synthetic
Glutamic acid mutant had reduced activity [...]
64
varv peptide F
Cyclotide
Viola tricolor Viola arvensis
All three cyclotides, varv A, varv F, and cycloviolacin O2, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. [...]
38
cycloviolacin O12
Cyclotide
Viola tricolor Viola arvensis Viola baoshanensis Viola yedoensis Viola tianshanica Viola abyssinica Viola philippica Viola arcuata
Vitri A, varv A and varv E shown to possess cytotoxic activity in cancer cells. [...]
37
kalata S
Cyclotide
Viola odorata Oldenlandia affinis Viola tricolor Viola arvensis Viola baoshanensis Viola yedoensis Viola biflora Viola philippica Viola ignobilis Viola uliginosa Viola sumatrana Miq Viola arcuata
All three cyclotides, varv A, varv F, and cycloviolacin O2, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. [...] Vitri A, varv A and varv E shown to possess cytotoxic activity in cancer cells. [...]
36
vitri A
Cyclotide
Viola tricolor Viola biflora Psychotria leptothyrsa
Vitri A, varv A and varv E shown to possess cytotoxic activity in cancer cells. [...]
27
cycloviolacin O8
Cyclotide
Viola odorata Viola baoshanensis Viola adunca Viola uliginosa
Cycloviolacin O8 showed micromolar anticancer activity against PC-3 prostate, MDA-MB-231 breast, and OVCAR-3 ovarian cancer cell lines and antifungal activity against the agricultural pathogenFusarium graminearum. [...]
21
cycloviolacin O2
Cyclotide
Viola odorata Hybanthus enneaspermus Viola baoshanensis Viola biflora Viola philippica Viola uliginosa Viola arcuata Viola austrosinensis
Cycloviolacin O2 showed antitumor effects are minor or absent at tolerable (sublethal) doses, and cycloviolacin O2 has a
very abrupt in vivo toxicity profile, with lethality after
single injection at 2 mg/kg, but no signs of discomfort to
the animals at 1.5 mg/kg. Repeated dosing of 1 mg/kg gave a local-inflammatory reaction at the site of injection after 2–3 days; lower doses were without complications. [...] Psyle A, psyle C, psyle E and cycloviolacin O2 shown to possess cytotoxic activity in cancer cells. [...] Studies using calcein assay and HeLa cells showed that at 10 uM, the increase in calcein leakage is very rapid. [...] Cell viability and morphology studies on the human lymphoma cell line U-937 GTB showed that cells exposed to cycloviolacin O2 displayed disintegrated cell membranes within 5 min. [...] All three cyclotides, varv A, varv F, and cycloviolacin O2, exhibited strong cytotoxic activities, which varied in a dose-dependent manner. [...] Glutamic acid mutant had reduced activity [...]