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Reference List

The references are sorted by year then first author.
Each reference is followed by a 'P' link and a 'NA' link that search the corresponding protein sequences and nucleic acid sequences, respectively.

Found 358 entries.


Rajendran,S., Slazak,B., Mohotti,S., Muhammad,T., Strömstedt,A.A., Kapusta,M., Wilmowicz,E., Göransson,U., Hettiarachchi,C.M., and Gunasekera,S.
Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from Geophila repens. J Nat Prod (2023) 86: 52-65 [P, NA]

Aslam,L., Kaur,R., Hussain,S., Kapoor,N., and Mahajan,R.
LC-MS/MS identification and structural characterization of isolated cyclotides from precursor sequences of Viola odorata L. petiole tissue using computational approach. J Biosci (2022) 47: 50-0 [P, NA]
Dang,T.T., Harvey,P.J., Chan,L.Y., Huang,Y.-H., Kaas,Q., Craik,D.J.
Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides Peptide Science (2022) : 0-0 [P, NA]
Du,Q., Huang,Y.H., Wang,C.K. and Craik,D.J.
Mutagenesis of bracelet cyclotide hyen D reveals functionally and structurally critical residues for membrane binding and cytotoxicity. J Biol Chem (2022) 298: 101822-0 [P, NA]
Fernández-Bobey,A., Pinto,M., de Almeida,L.C., de Souza,B.M., Dias,N.B., de Paula-Souza,J., Cilli,E.M., Lopes,N.P., Costa-Lotufo,L.V., Palma,M.S., and da Silva Bolzani,V.
Cytotoxic Cyclotides from Anchietea pyrifolia, a South American Plant Species. J Nat Prod (2022) 85: 2127-2134 [P, NA]
Gerlach,S.L., Dunlop,R.A., Metcalf,J.S., Banack,S.A., and Cox,P.A.
Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide. J Nat Prod (2022) 85: 34-46 [P, NA]
Slazak, B., J?drzejska, A., Badyra,B., Shariatgorji,R., Nilsson,A., Andrén,P.E., and Göransson,U.
The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures. Plants (Basel) (2022) 11: 1876-0 [P, NA]
Taghizadeh,M.S., Retzl,B., Muratspahi?,E., Trenk,C., Casanova,E., Moghadam,A., Afsharifar,A., Niazi,A., and Gruber,C.W.
Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor. Sci Rep (2022) 12: 9215-0 [P, NA]
Tian, S., Durek, T., Wang, C.K., Zdenek, C.N., Fry, B.G., Craik, D.J., and de Veer, S.J.
Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa. J Med Chem (2022) 65: 15698-15709 [P, NA]

Aslam,L., Kaur,R., Sharma,V., Kapoor,N. and Mahajan,R.
Isolation and characterization of cyclotides from the leaves of Viola odorata L. using peptidomic and bioinformatic approach. 3 Biotech (2021) 11: 211-0 [P, NA]
Dang,T.T., Chan,L.Y., Tombling,B.J., Harvey,P.J., Gilding,E.K. and Craik,D.J.
In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis. J Nat Prod (2021) 84: 395-407 [P, NA]
Gattringer J, Ndogo OE, Retzl B, Ebermann C, Gruber CW, Hellinger R.
Cyclotides Isolated From Violet Plants of Cameroon Are Inhibitors of Human Prolyl Oligopeptidase. Front Pharmacol (2021) 12: 707596-0 [P, NA]
Hellinger,R., Muratspahi?,E., Devi,S., Koehbach,J., Vasileva,M., Harvey,P.J., Craik,D.J. and Gruber,C.W.
Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides. ACS Chem Biol (2021) 16: 2373-2386 [P, NA]
Huang,Y.H., Du,Q., Jiang,Z., King,G.J., Collins,B.M. and Craik,D.J.
Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules (2021) 26: 0-0 [P, NA]
Liu W, de Veer SJ, Huang YH, Sengoku T, Okada C, Ogata K, Zdenek CN, Fry BG, Swedberg JE, Passioura T, Craik DJ, Suga H.
An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold J Am Chem Soc (2021) 143: 18481-18489 [P, NA]
Payne,C.D., Franke,B., Fisher,M.F., Hajiaghaalipour,F., McAleese,C.E., Song,A., Eliasson,C., Zhang,J., Jayasena, A.S., Vadlamani,G., Clark,R.J., Minchin,R.F., Mylne,J.S., Rosengren,K.J.
A chameleonic macrocyclic peptide with drug delivery applications. Chemical science (2021) 12: 6670-6683 [P, NA]
Payne,C.D., Vadlamani,G., Hajiaghaalipour,F., Muhammad,T., Fisher,M F., Andersson,H.S., Göransson,U., Clark,R.J., Bond,C.S., Mylne,J.S., Rosengren,K.J.
Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides. RSC chemical biology (2021) 2: 1682-1691 [P, NA]
Pinto,M.E.F., Chan,L.Y., Koehbach,J., Devi,S., Gründemann,C., Gruber,C.W., Gomes,M., Bolzani,V.S., Cilli,E.M., and Craik,D.J.
Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes. J Nat Prod (2021) 84: 81-90 [P, NA]
Rajendran,S., Slazak,B., Mohotti,S., Strömstedt,A.A., Göransson,U. and Gunasekera,S.
Tropical vibes from Sri Lanka - cyclotides from Viola betonicifolia by transcriptome and mass spectrometry analysis. Phytochemistry (2021) 187: 112749-0 [P, NA]
Slazak,B., Kaltenböck,K., Steffen,K., Rogala,M., Rodríguez-Rodríguez,P., Nilsson,A., Shariatgorji,R. and Göransson,U.
Cyclotide host-defense tailored for species and environments in violets from the Canary Islands. Sci Rep (2021) 11: 12452-0 [P, NA]

Dancewicz,K., Slazak,B., Kie?kiewicz,M., Kapusta,M., Bohdanowicz,J., and Gabry?,B.
Behavioral and physiological effects of Viola spp. cyclotides on Myzus persicae (Sulz.) Journal of Insect Physiology (2020) 122: 104025-0 [P, NA]
Dang,T.T., Chan,L.Y., Huang,Y.H., Nguyen,L.T.T., Kaas,Q., Huynh,T. and Craik,D.J.
Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species. J Nat Prod (2020) 83: 1817-1828 [P, NA]
Du, J., Yap, K., Chan, L.Y., Rehm, F.B., Looi, F.Y., Poth, A.G., Gilding, E.K., Kaas, Q., Durek, T. and Craik, D.J.
A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors Nature communications (2020) 11: 1575-0 [P, NA]
Du,Q., Chan,L.Y., Gilding,E.K., Henriques,S.T., Condon,N.D., Ravipati,A.S., Kaas,Q., Huang,Y.H. and Craik,D.J.
Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. J Biol Chem (2020) 295: 10911-10925 [P, NA]
Du,Q., Huang,Y.H., Bajpai,A., Frosig-Jorgensen,M., Zhao,G. and Craik,D.J.
Evaluation of the in Vivo Aphrodisiac Activity of a Cyclotide Extract from Hybanthus enneaspermus. J Nat Prod (2020) : 0-0 [P, NA]
Fisher, M.F., Zhang, J., Berkowitz, O., Whelan, J. and Mylne, J.S.
Cyclic Peptides in Seed of Annona muricata Are Ribosomally Synthesized Journal of Natural Products. (2020) 83: 1167-1173 [P, NA]
Kalmankar,N.V., Venkatesan,R., Balaram,P. and Sowdhamini,R.
Transcriptomic profiling of the medicinal plant Clitoria ternatea: identification of potential genes in cyclotide biosynthesis. Sci Rep (2020) 10: 12658-0 [P, NA]
Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S.
Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of Papain Superfamily Cysteine Proteases. Pharmaceuticals (Basel) (2020) 14: 1-17 [P, NA]
Oguis, G.K., Gilding, E.K., Huang, Y.H., Poth, A.G., Jackson, M.A. and Craik, D.J.
Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions Industrial Crops and Products (2020) 147: 112214-0 [P, NA]
Parsley,N.C., Williams,O.L. and Hicks,L.M.
Exploring the Diversity of Cysteine-Rich Natural Product Peptides via MS/MS Fingerprint Ions. J Am Soc Mass Spectrom (2020) 31: 1833-1843 [P, NA]
Smithies, B.J., Huang, Y.H., Jackson, M.A., Yap, K., Gilding, E.K., Harris, K.S., Anderson, M.A. and Craik, D.J.,
Circular permutation of the native enzyme-mediated cyclization position in cyclotides ACS Chemical Biology (2020) 15: 962-969 [P, NA]
Zou, X.G., Li, J., Sun, P.L., Fan, Y.W., Yang, J.Y. and Deng, Z.Y.
Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells International Journal of Food Sciences and Nutrition (2020) : 1-11 [P, NA]

Du J, Chan LY, Poth AG, Craik DJ
Discovery and Characterization of Cyclic and Acyclic Trypsin Inhibitors from Momordica dioica. J Nat Prod. (2019) 82: 293-300 [P, NA]
Fisher, M.F., Payne, C.D., Rosengren, K.J. and Mylne, J.S.
An orbitide from Ratibida columnifera seed containing 16 amino acid residues J Nat Prod (2019) 82: 2152-2158 [P, NA]
Parsley, Nicole C., Patric W. Sadecki, Conrad J. Hartmann, and Leslie M. Hicks
Viola "inconspicua" No More: An Analysis of Antibacterial Cyclotides. J Nat Prod (2019) 82: 2537-2543 [P, NA]
Poth, A.G., Huang, Y.H., Le, T.T., Kan, M.W. and Craik, D.J.,
Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold Int J Pharm (2019) 565: 437-446 [P, NA]
Sternberger,A.L., Bowman,M.J., Kruse,C.P.S., Childs,K.L., Ballard, H.E., and Wyatt,S.E.
Transcriptomics Identifies Modules of Differentially Expressed Genes and Novel Cyclotides in Viola pubescens. Front Plant Sci (2019) 10: 156-0 [P, NA]

Álvarez, C.A., Santana, P.A., Luna, O., Cárdenas, C., Albericio, F., Romero, M.S., and Guzmán, F.
Chemical Synthesis and Functional Analysis of VarvA Cyclotide Molecules (2018) 23: 952-0 [P, NA]
Bobey,A.F., Pinto,M.E.F., Cilli,E.M., Lopes,N.P. and Bolzani,V.D.S.
A Cyclotide Isolated from Noisettia orchidiflora (Violaceae). Planta Med. (2018) 84: 947-952 [P, NA]
Fisher, M.F., Zhang, J., Taylor, N.L., Howard, M.J., Berkowitz, O., Debowski, A.W., Behsaz, B., Whelan, J., Pevzner, P.A. and Mylne, J.S.
A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch Plant direct (2018) 2: 0-0 [P, NA]
Keov,P., Liutkevi?i?t?,Z., Hellinger,R. and Gruber,C.W.
Discovery of peptide probes to modulate oxytocin-type receptors of insects. Sci Rep (2018) 8: 10020-0 [P, NA]
Kwon, S., Duarte, J.N., Li, Z., Ling, J.J., Cheneval, O., Durek, T., Schroeder, C.I., Craik, D.J. and Ploegh, H.L.
Targeted delivery of cyclotides via conjugation to a nanobody ACS chemical biology (2018) 13: 2973-2980 [P, NA]
Niyomploy, P., Chan, L.Y., Harvey, P.J., Poth, A.G., Colgrave, M.L. and Craik, D.J
Discovery and characterization of cyclotides from Rinorea species Journal of natural products (2018) 81: 2512-2520 [P, NA]
Parsley, N.C., Kirkpatrick, C.L., Crittenden, C.M., Rad, J.G., Hoskin, D.W., Brodbelt, J.S. and Hicks, L.M.
PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata Phytochemistry (2018) 152: 61-70 [P, NA]
Pinto,M.E.F., Najas,J.Z.G., Magalhães,L.G., Bobey,A.F., Mendonça,J.N., Lopes,N.P., Leme,F.M., Teixeira,S.P., Trovó,M., Andricopulo,A.D., Koehbach,J., Gruber,C.W., Cilli,E.M. and Bolzani,V.S.
Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. J. Nat. Prod. (2018) 81: 1203-1208 [P, NA]
Ramalho, S.D., Pinto, M.E.F., Ferreira, D. and Bolzani, V.S.
Biologically active orbitides from the Euphorbiaceae family Planta medica (2018) 84: 558-567 [P, NA]
Slazak,B., Kapusta,M., Strömstedt,A.A., S?omka,A., Krychowiak,M., Shariatgorji,M., Andrén,P.E., Bohdanowicz,J., Kuta,E., and Göransson,U.
How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System Frontiers in plant science (2018) 9: 0-0 [P, NA]
Zou, X.G., Hu, J.N., Li, J., Yang, J.Y., Du, Y.X., Yu, Y.F. and Deng, Z.Y
iCellular uptake of [1–9-N?C]-linusorb B2 and [1–9-N?C]-linusorb B3 isolated from flaxseed, and their antitumor activities in human gastric SGC-7901 cells Journal of Functional Foods (2018) 48: 692-703 [P, NA]

Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P.J., Ghassempour, A. and Gruber, C.W.
Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor Frontiers in pharmacology (2017) 8: 616-0 [P, NA]
Hellinger, R., Thell, K., Vasileva, M., Muhammad, T., Gunasekera, S., Kümmel, D., Göransson, U., Becker, C.W. and Gruber, C.W
Chemical proteomics for target discovery of head-to-tail cyclized mini-proteins Frontiers in chemistry (2017) 5: 73-0 [P, NA]
Jayasena, A.S., Fisher, M.F., Panero, J.L., Secco, D., Bernath-Levin, K., Berkowitz, O., Taylor, N.L., Schilling, E.E., Whelan, J. and Mylne, J.S
Stepwise evolution of a buried inhibitor peptide over 45 My Molecular biology and evolution (2017) 34: 1505-1516 [P, NA]
Kirkpatrick, C.L., Broberg, C.A., McCool, E.N., Lee, W.J., Chao, A., McConnell, E.W., Pritchard, D.A., Hebert, M., Fleeman, R., Adams, J. and Jamil, A.
The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery Analytical chemistry (2017) 89: 1194-1201 [P, NA]
Lesniak, W.G., Aboye, T., Chatterjee, S., Camarero, J.A. and Nimmagadda, S.
In vivo evaluation of an engineered cyclotide as specific CXCR4 imaging reagent Chemistry (2017) 23: 14469-14475 [P, NA]
Narayani, M., Chadha, A. and Srivastava, S
Cyclotides from the indian medicinal plant Viola odorata (Banafsha): Identification and characterization Journal of natural products (2017) 80: 1972-1980 [P, NA]
Nworu, C.S., Ejikeme, T.I., Ezike, A.C., Ndu, O., Akunne, T.C., Onyeto, C.A., Okpalanduka, P. and Akah, P.A.
Anti-plasmodial and anti-inflammatory activities of cyclotide-rich extract and fraction of Oldenlandia affinis (R. & S.) DC (Rubiaceae) African health sciences (2017) 17: 827-843 [P, NA]
Ravipati AS, Poth AG, Troeira Henriques S, Bhandari M, Huang YH, Nino J, Colgrave ML, Craik DJ.
Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin. J Nat Prod. (2017) 80: 1522-1530 [P, NA]

Wang, D., Chen, J., Zhu, J. and Mou, Y.
Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 [P, NA]
Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ
Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies. Biopolymers (2016) : 0-0 [P, NA]
Aboye, T., Meeks, C.J., Majumder, S., Shekhtman, A., Rodgers, K. and Camarero, J.A
Design of a MCoTI-based cyclotide with angiotensin (1-7)-like activity Molecules (2016) 21: 152-0 [P, NA]
Attah,A.F., Hellinger,R., Sonibare,M.A., Moody,J.O., Arrowsmith,S., Wray,S. and Gruber,C.W.
Ethnobotanical survey of Rinorea dentata (Violaceae) used in South-Western Nigerian ethnomedicine and detection of cyclotides. J Ethnopharmacol (2016) 179: 83-91 [P, NA]
Burnett, P.G.G., Olivia, C.M., Okinyo-Owiti, D.P. and Reaney, M.J.T.
Orbitide composition of the flax Core collection (FCC) Journal of agricultural and food chemistry (2016) 64: 5197-5206 [P, NA]
Cunha NB, Barbosa AE, de Almeida RG, Porto WF, Maximiano MR, Álvares LC, Munhoz CB, Eugênio CU, Viana AA, Franco OL, Dias SC
Cloning and characterization of novel cyclotides genes from South American plants Peptide Science (2016) 106: 784-795 [P, NA]
Dos S Beirigo,P.J., Torquato,H.F., Dos Santos,C.H., Carvalho,M.G., Castro,R.N., Paredes-Gamero,E.J., de Sousa,P.T. Jr. and da Silva,V.C.
[1-8-N?C]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum. J Nat Prod (2016) 79: 1454-1458 [P, NA]
Esmaeili,M.A., Abagheri-Mahabadi,N., Hashempour,H., Farhadpour,M., Gruber,C.W. and Ghassempour,A.
Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells. Fitoterapia (2016) 109: 162-168 [P, NA]
Farhadpour,M., Hashempour,H., Talebpour,Z., A-Bagheri,N., Shushtarian,M.S., Gruber,C.W. and Ghassempour,A.
Microwave-assisted extraction of cyclotides from Viola ignobilis. Anal. Biochem. (2016) 497: 83-89 [P, NA]
Gilding,E.K., Jackson,M.A., Poth,A.G., Henriques,S.T., Prentis,P.J., Mahatmanto,T. and Craik,D.J.
Gene coevolution and regulation lock cyclic plant defence peptides to their targets. New Phytol. (2016) 210: 717-730 [P, NA]
Glantz,S.T., Carpenter,E.J., Melkonian,M., Gardner,K.H., Boyden,E.S., Wong,G.K. and Chow,B.Y.
Functional and topological diversity of LOV domain photoreceptors. Proc. Natl. Acad. Sci. U.S.A. (2016) 113: 0-51 [P, NA]
Matsuura HN, Poth AG, Yendo AC, Fett-Neto AG, Craik DJ.
Isolation and Characterization of Cyclotides from Brazilian Psychotria: Significance in Plant Defense and Co-occurrence with Antioxidant Alkaloids. J Nat Prod. (2016) 79: 3006-3013 [P, NA]
Nguyen KN, Nguyen GK, Nguyen PQ, Ang KH, Dedon PC, Tam JP
Immunostimulating and Gram-negative-specific Antibacterial Cyclotides from the Butterfly Pea Clitoria ternatea. FEBS J (2016) doi:10.1111/febs.13720: 0-0 [P, NA]
Niyomploy, P., Chan, L.Y., Poth, A.G., Colgrave, M.L., Sangvanich, P. and Craik, D.J.
Discovery, isolation, and structural characterization of cyclotides from Viola sumatrana Miq Peptide Science (2016) 106: 796-805 [P, NA]
Pinto, M.F., Silva, O.N., Viana, J.C., Porto, W.F., Migliolo, L., B. da Cunha, N., Gomes Jr, N., Fensterseifer, I.C., Colgrave, M.L., Craik, D.J. and Dias, S.C
Characterization of a Bioactive Acyclotide from Palicourea rigida Journal of natural products (2016) 79: 2767-2773 [P, NA]
Serra,A., Hemu,X., Nguyen,G.K., Nguyen,N.T., Sze,S.K. and Tam,J.P.
A high-throughput peptidomic strategy to decipher the molecular diversity of cyclic cysteine-rich peptides. Sci Rep (2016) 6: 23005-0 [P, NA]
Strömstedt,A.A., Kristiansen,P.E., Gunasekera,S., Grob,N., Skjeldal,L. and Göransson,U.
Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket. Biochim Biophys Acta (2016) 1858: 1317-1327 [P, NA]
Thell K, Hellinger R, Sahin E, Michenthaler P, Gold-Binder M, Haider T, Kuttke M, Liutkevi?i?t? Z, Göransson U, Gründemann C, Schabbauer G, Gruber CW
Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis Proc Natl Acad Sci USA (2016) 113: 3960-3965 [P, NA]
Wang, D., Chen, J., Zhu, J. and Mou, Y.
Novel cyclotides from Hedyotis biflora has potent bactericidal activity against Gram-negative bacteria and E. coli drug resistance Int. J. Clin. Exp. Med (2016) 9: 9521-9526 [P, NA]

Burman, R., Yeshak, M.Y., Larsson, S., Craik, D.J., Rosengren, K.J. and Göransson, U.
Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae Frontiers in plant science (2015) 6: 855-0 [P, NA]
Burnett, P.G.G., Jadhav, P.D., Okinyo-Owiti, D.P., Poth, A.G. and Reaney, M.J.
Glycine-containing flaxseed orbitides Journal of natural products (2015) 78: 681-688 [P, NA]
Cândido-Bacani, P.D.M., Figueiredo, P.D.O., Matos, M.D.F., Garcez, F.R. and Garcez, W.S.
Cytotoxic orbitide from the latex of Croton urucurana Journal of natural products (2015) 78: 2754-2760 [P, NA]
Hellinger,R., Koehbach,J., Puigpinós,A., Clark,R.J., Tarragó,T., Giralt,E. and Gruber,C.W.
Inhibition of Human Prolyl Oligopeptidase Activity by the Cyclotide Psysol 2 Isolated from Psychotria solitudinum. J. Nat. Prod. (2015) 78: 1073-1082 [P, NA]
Hellinger,R., Koehbach,J., Soltis,D.E., Carpenter,E.J., Wong,G.K. and Gruber,C.W.
Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining. J. Proteome Res. (2015) 14: 4851-4862 [P, NA]
Hu E, Wang D, Chen J, Tao X.
Novel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells Int J Clin Exp Med (2015) 8: 4059-4065 [P, NA]
Huang,Y.H., Henriques,S.T., Wang,C.K., Thorstholm,L., Daly,N.L., Kaas,Q. and Craik,D.J.
Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Sci Rep (2015) 5: 12974-0 [P, NA]
Mahatmanto, T., Mylne, J.S., Poth, A.G., Swedberg, J.E., Kaas, Q., Schaefer, H. and Craik, D.J.
The evolution of Momordica cyclic peptides. Molecular biology and evolution 32 (2015) 2: 392-405 [P, NA]
Pinto,M.E., Batista,J.M. Jr., Koehbach,J., Gaur,P., Sharma,A., Nakabashi,M., Cilli,E.M., Giesel,G.M., Verli,H., Gruber,C.W., Blanch,E.W., Tavares,J.F., da Silva,M.S., Garcia,C.R. and Bolzani,V.S.
Ribifolin, an orbitide from Jatropha ribifolia, and its potential antimalarial activity. J. Nat. Prod. (2015) 78: 374-380 [P, NA]
Ravipati,A.S., Henriques,S.T., Poth,A.G., Kaas,Q., Wang,C.K., Colgrave,M.L. and Craik,D.J.
Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae. ACS Chem. Biol. (2015) 10: 2491-2500 [P, NA]
Slazak, B., Jacobsson, E., Kuta, E. and Göransson, U.
Exogenous plant hormones and cyclotide expression in Viola uliginosa (Violaceae Phytochemistry (2015) 117: 527-536 [P, NA]
Zhang, J., Li, J., Huang, Z., Yang, B., Zhang, X., Li, D., Craik, D.J., Baker, A.J., Shu, W. and Liao, B.
Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis. Journal of plant physiology (2015) 178: 17-26 [P, NA]

Altei,W.F., Picchi,D.G., Abissi,B.M., Giesel,G.M., Flausino,O. Jr., Reboud-Ravaux,M., Verli,H., Crusca,E. Jr., Silveira,E.R., Cilli,E.M. and Bolzani,V.S.
Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: isolation, characterization, conformational studies and biological activity. Phytochemistry (2014) 107: 91-96 [P, NA]
Ding, X., Bai, D. and Qian, J
Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo Medicinal Chemistry Research (2014) 23: 1406-1413 [P, NA]
Elliott,A.G., Delay,C., Liu,H., Phua,Z., Rosengren,K.J., Benfield,A.H., Panero,J.L., Colgrave,M.L., Jayasena,A.S., Dunse,K.M., Anderson,M.A., Schilling,E.E., Ortiz-Barrientos,D. and Mylne,J.S.
Evolutionary origins of a bioactive peptide buried within Preproalbumin. Plant Cell (2014) 26: 981-995 [P, NA]
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Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem (2014) 15: 1956-1965 [P, NA]
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Semienzymatic cyclization of disulfide-rich peptides using Sortase A. J Biol Chem (2014) 289: 6627-6638 [P, NA]
Mu,F., Masuda,Y., Zendo,T., Ono,H., Kitagawa,H., Ito,H., Nakayama,J. and Sonomoto,K.
Biological function of a DUF95 superfamily protein involved in the biosynthesis of a circular bacteriocin, leucocyclicin Q. J. Biosci. Bioeng. (2014) 117: 158-164 [P, NA]
Okinyo-Owiti, D.P., Young, L., Burnett, P.G.G. and Reaney, M.J.
New flaxseed orbitides: Detection, sequencing, and 15N incorporation Peptide Science (2014) 102: 168-175 [P, NA]
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Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angew Chem Int Ed Engl (2014) 53: 11236-11241 [P, NA]

Hashempour,H., Koehbach,J., Daly,N.L., Ghassempour,A. and Gruber,C.W.
Characterizing circular peptides in mixtures: sequence fragment assembly of cyclotides from a violet plant by MALDI-TOF/TOF mass spectrometry. Amino Acids (2013) 44: 581-595 [P, NA]
Ji,Y., Majumder,S., Millard,M., Borra,R., Bi,T., Elnagar,A.Y., Neamati,N., Shekhtman,A. and Camarero,J.A.
In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. J. Am. Chem. Soc. (2013) 135: 11623-11633 [P, NA]
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Cyclotide discovery in Gentianales revisited-identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. Biopolymers (2013) 100: 438-452 [P, NA]
Koehbach,J., O Brien,M., Muttenthaler,M., Miazzo,M., Akcan,M., Elliott,A.G., Daly,N.L., Harvey,P.J., Arrowsmith,S., Gunasekera,S., Smith,T.J., Wray,S., Goransson,U., Dawson,P.E., Craik,D.J., Freissmuth,M. and Gruber,C.W.
Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc. Natl. Acad. Sci. U.S.A (2013) 110: 21183-21188 [P, NA]
Nguyen,G.K., Lian,Y., Pang,E.W., Nguyen,P.Q., Tran,T.D. and Tam,J.P.
Discovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J. Biol. Chem. (2013) 288: 3370-3380 [P, NA]
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Comparison of the antimicrobial effects of semipurified cyclotides from Iranian Viola odorata against some of plant and human pathogenic bacteria. J. Appl. Microbiol. (2013) 115: 367-375 [P, NA]

Aboye,T.L., Ha,H., Majumder,S., Christ,F., Debyser,Z., Shekhtman,A., Neamati,N. and Camarero,J.A.
Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. J. Med. Chem. (2012) 55: 10729-10734 [P, NA]
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Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1. J. Biol. Chem. (2012) 287: 40493-40501 [P, NA]
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Novel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities. J. Biol. Chem. (2012) 287: 17598-17607 [P, NA]
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Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane. J Biol Chem (2012) 287: 134-147 [P, NA]
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Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations. Angew. Chem. Int. Ed. Engl. (2012) 51: 3708-3712 [P, NA]
Wong,C.T., Rowlands,D.K., Wong,C.H., Lo,T.W., Nguyen,G.K., Li,H.Y. and Tam,J.P.
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Borrero J, Brede DA, Skaugen M, Diep DB, Herranz C, Nes IF, Cintas LM, Hernández PE
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Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides. J. Biol. Chem. (2011) 286: 36932-36943 [P, NA]
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Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem Biol (2011) 6: 345-355 [P, NA]
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Identification of two suites of cyclotide precursor genes from metallophyte Viola baoshanensis: cDNA sequence variation, alternative RNA splicing and potential cyclotide diversity Gene (2009) 431: 23-32 [P, NA]

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Levesque MP, Twigg RW, Motley T, Katari MS, Dedhia NN, O'Shaughnessy AL, Balija V, Martienssen RA, McCombie RW, Benfey P, Stevenson D (Unpublished)
Zhang J, Shu W, Liao B (Unpublished)