BiKK(95) Protein Card

General Information
Name BiKK
Sequence PICTKSIPPICTKSIP
Class BBI-like trypsin inhibitor
Average Mass 1678.08
Monoisotopic Mass 1676.9
m/z M+H 1677.91
ProteinType Mutant
Parent SFTI-1
Organism Synthetic
Notes Cyclic SFT-1 with two active sites.
Cyclic Yes

Assay
Protease inhibition
Bifunctional analogues of SFTI-1 found to have trypsin and chymotrypsin inhibitory activity. [...]Jaulent AM and Leatherbarrow RJ (2004) Protein Eng Des Sel 17:681-7
Enzymatic Digest
Bifunctional analogues of SFTI-1 found to be resistant to hydrolysis by trypsin. [...]Jaulent AM and Leatherbarrow RJ (2004) Protein Eng Des Sel 17:681-7

References
Jaulent AM, Leatherbarrow RJ (2004) Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors. Protein Eng Des Sel 17:681-7
Jaulent AM, Brauer AB, Matthews SJ, Leatherbarrow RJ (2005) Solution structure of a novel C2-symmetrical bifunctional bicyclic inhibitor based on SFTI-1. J Biomol NMR 33:57-62

Cross-references
Nucleic acids
Structure SOLUTION STRUCTURE OF A NOVEL C2 SYMMETRICAL BIFUNCTIONAL BICYCLIC INHIBITOR BASED ON SFTI-1
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