varv peptide B[del8](2084) Protein Card

General Information
Name varv peptide B[del8]
Sequence GLPVCGECFGGTCNTPGCSCDPWPMCSRN
Class Cyclotide
Technique MS
Average Mass 2968.35
Monoisotopic Mass 2966.08
m/z M+H 2968.35
ProteinType Modified Wild Type
Parent varv peptide B
Organism Viola arvensis
Notes varv peptide B[del8] was named by Cybase. The cyclotide was named VarvA, which is also known as varv peptide A, by Álvarez et al. (2018); however, the cyclotide sequence is highly similar to varv peptide B sequence.
Cyclic Yes

Assay
Anti-bacterial
Values of minimal inhibitory concentration (MIC) varv peptide B[del8] on different Gram-negative bacterial fish pathogens. F. psychrophilum was the bacteria most susceptible, with an MIC of 12.5 +/- 0.3 uM. [...]Álvarez et al. (2018) Molecules 23:952-0

References
Goransson U, Luijendijk T, Johansson S, Bohlin L, Claeson P (1999) Seven novel macrocyclic polypeptides from Viola arvensis. J Nat Prod 62:283-6
Álvarez, C.A., Santana, P.A., Luna, O., Cárdenas, C., Albericio, F., Romero, M.S., and Guzmán, F. (2018) Chemical Synthesis and Functional Analysis of VarvA Cyclotide Molecules 23:952-0

Cross-references
Nucleic acids
Structure
Links

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