(41) Assay Card

General Information
Summary Peptide antibiotic AS-48 exerts a bactericidal mode of action on exponential cultures of Escherichia coli K-12 through a multi-hit kinetics interaction.
Result AS-48 causes a parallel and gradual cessation of all biosynthetic pathways monitored (protein, RNA, DNA, and cell wall synthesis), the rate of incorporation of labeled precursors, the rate of O2 consumption, and cell growth. These effects have been attributed to alterations of cytoplasmic membrane functions.
AssayType Anti-bacterial

Galvez A, Valdivia E, Martinez M, Maqueda M (1989) Bactericidal action of peptide antibiotic AS-48 against Escherichia coli K-12. Can J Microbiol 35:318-21

Proteins Assayed Ent AS-48