Result |
(i) IC50 Best Fit for CyO2, CyO13, kalata B1, varv peptide A and TMZ against SH-SY5Y cells were 2.15 uM, 2.15 uM, 5.56 uM, 2.88 uM and 393.00 uM, respectively. (ii) IC50 Best Fit for CyO2, CyO13, kalata B1, varv peptide A and temozolomide (TMZ) against U-87 MG cells were 4.50 uM, 2.57 uM, 7.93 uM, 2.91 uM and 2898.00 uM, respectively. (iii) Co-incubation of CyO2 (0.27 uM, 8-fold less than the IC Best Fit value for CyO2 alone in SH-SY5Y cells) and TMZ (216.20 uM, 1.8 fold-less than the IC Best Fit value for TMZ alone in SH-SY5Y cells) with SH-SY5Y cells caused 50% cell death. (iv) Co-incubation of CyO2 (4.50 uM) and TMZ (352.00 uM or 1408.00 uM) with U-87 MG cells increased cell death by approximately 20%. (v) Co-incubation of varv peptide A (4.20 uM) and TMZ (1408.00 uM, 2 fold-less than the IC Best Fit value for TMZ alone in U-87 MG cells) with U-87 MG cells resulted in a significant increase in U-87 MG cell death. |